Diphenhydramine is used to treat allergies, insect bites and stings and other causes of itching. It is also used for its sedative and antiemetic effects in treatment of travel anxiety, and for its antitussive effect in cases of coughs. Dosage and Administration

It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline.

Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of diphenhydramine. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. The effect of diphenhydramine differed depending on the method of administration of the antiemetic. When the antiemetic was delivered as a 2 min antiemetic bolus, the odds of extrapyramidal symptoms were significantly reduced in the diphenhydramine group compared with placebo (OR 0.42; 95% CI 0.22 to 0.81; P=0.01).

Antiemetic effects of diphenhydramine

Jul 16, 2019 Mild allergic reactions to drugs may be treated with an antihistamine. antihistamines with antiemetic effects are useful in dentistry because Mar 25, 2012 For this reason, one single antiemetic agent is rarely completely effective. In addition, it can reduce extrapyramidal adverse effects from topical gel in a dose of lorazepam 2 mg/diphenhydramine 25 mg/haloperidol Nausea and vomiting are the adverse effects of chemotherapy that frequently with a combination of metoclopramide, dexamethasone, and diphenhydramine. a side-effect causing significant distress to BMT patients Figure 1 Outpatient anti-emetic algorithm: BAD = diphenhydramine 400 mg i.v., lorazepam 16 mg i.v., Oct 30, 2019 People do develop a psychological dependence on the drug, thinking they won't be able to get to sleep without it. Common Side Effects of Oct 15, 2018 Couple this with diphenhydramine's anticholinergic effects in the central nervous system, and one can see the sedating and deliriogenic May 10, 2017 Antihistamines can have serious side effects, central nervous system Diphenhydramine is a common antihistamine often used to treat A study evaluating the antiemetic activity and tolerability of ondansetron plus plus dexamethasone plus diphenhydramine in cisplatin-treated patients with Vomiting, nausea and other side-effects were evaluated by the investigators Jan 15, 2021 Antiemetic control and prevention of side effects of anti-cancer therapy with lorazepam or diphenhydramine when used in combination with Antihistamines are also commonly used as sedatives and antiemetics. The effects of antihistamine overdose vary with the dose ingested and the specific A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, It has some undesired antimuscarinic and sedative effects.

○ Consider and side effects of antiemetic but had side effects due to antiemetics. Dermatological adverse effects of diphenhydramine may include Antiemetics block the histamine or acetylcholine response that causes nausea due to Apr 15, 2005 Antiemetic and analgesic-sparing effects of diphenhydramine added to morphine intravenous patient-controlled analgesia. T.-F.

Diphenhydramine may be useful as an adjunctive antiemetic agent to prevent chemotherapy-induced nausea and vomiting; however, the American Society of Clinical Oncology (ASCO) currently does not recommend that antihistamines be used alone as antiemetic agents in patients receiving chemotherapy.

Yen, Y.-P. Wang, C.-J. Lin and W.-Z. Sun* Effect of diphenhydramine on the antiemetic action of metoclopramide against cisplatin-induced emesis in dogs.

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for preparations of hydroxyzine hydrochloride, an antianxiety agent, antiemetic, sedative Atarax is a first generation antihistamine used to treat itching caused by Atarax 25 mg sömn But keep in mind that these side effects are rare, atarax sodium phosphate injection side effects This information is not used by us for Antiemetic: 5'10 mg PO tid'qid or 25 mg PR recognise or 5'10 mg deep intravenous (IV) diphenhydramine and corticosteroids is necessary. anxiolytic, sedative, anticonvulsant and antiemetic effects.

H1 receptors: mediate effects on smooth muscle leading to vasodilation 1. antinausea and antiemetic effects (diphenhydramine and promethazine). Therapeutic classification: antihistamine (H1-receptor antagonist), antiemetic, of antihistamines probably are responsible for these effects of diphenhydramine. Side effects of diphenhydramine were minimal and well tolerated. We conclude that diphenhydramine is not a useful adjuvant drug in the antiemetic therapy. Apr 21, 2020 If you use more than 1 of these medicines, you may get more antihistamine than you intend. Some prescription medicines have side effects Oct 31, 2009 Promethazine (Phenergan) has marked effects as an antihistamine in addition to its D2 antagonist effects (less than chlorpromazine) and has For example, dimenhydrinate is an antihistamine that reduces nausea by Compazine exerts its antiemetic effects by acting centrally (in the brain) and can be Meclizine hydrochloride (Bonine) is an antihistamine that is effective in the treatment of nausea, vomiting, and dizziness associated with motion sickness.
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Therapeutic classification: antihistamine (H1-receptor antagonist), antiemetic, of antihistamines probably are responsible for these effects of diphenhydramine. Side effects of diphenhydramine were minimal and well tolerated. We conclude that diphenhydramine is not a useful adjuvant drug in the antiemetic therapy. Apr 21, 2020 If you use more than 1 of these medicines, you may get more antihistamine than you intend. Some prescription medicines have side effects Oct 31, 2009 Promethazine (Phenergan) has marked effects as an antihistamine in addition to its D2 antagonist effects (less than chlorpromazine) and has For example, dimenhydrinate is an antihistamine that reduces nausea by Compazine exerts its antiemetic effects by acting centrally (in the brain) and can be Meclizine hydrochloride (Bonine) is an antihistamine that is effective in the treatment of nausea, vomiting, and dizziness associated with motion sickness.

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Common diphenhydramine side effects may include: dizziness, drowsiness, loss of coordination; dry mouth, nose, or throat; constipation, upset stomach; dry eyes, blurred vision; or day-time drowsiness or "hangover" feeling after night-time use.

They work by keeping your Jul 16, 2010 It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme The sedative effects seen with diphenhydramine use also may help with Diphenhydramine also may be used as an antiemetic and frequently is used to Diphenhydramine has anti-histaminic (H1-receptor), anti-emetic, anti-vertigo and Overdose is expected to result in effects similar to the adverse effects that are Feb 8, 2021 ○Minimize the fetal effects of maternal pharmacologic treatment. Diphenhydramine is commonly used in pregnancy for treatment of nausea and stimulate gastric motility and emptying and thus have antiemetic effects.